IntronA in combination with ribavirin is also linked to weight loss and reduced growth in children and adolescents. For a list of all restrictions with IntronA, see the package leaflet.īecause IntronA is linked to side effects such as depression, patients must be closely monitored during treatment.
It must not be used in patients who have had severe heart disease or certain immune-system disorders, in patients who are taking medicines that suppress the immune system, in hepatitis patients who have liver cirrhosis (scarring) that is causing symptoms or who have recently received medicines that affect the immune system, or in children or adolescents with a history of severe mental illness, particularly severe depression, thoughts about committing suicide or suicide attempts. IntronA must not be used in patients with severe kidney or liver disease, epilepsy or other central-nervous-system problems, or thyroid disease that is not controlled.
IntronA should not be used in people who may be hypersensitive (allergic) to interferon alfa-2b or any of the other ingredients.
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For the full list of all side effects reported with IntronA, see the package leaflet. In children and adolescents receiving IntronA in combination with ribavirin, side effects were similar to adults, although anaemia (low red blood cell counts), neutropenia (low levels of neutrophils, a type of white blood cell), hypothyroidism (underactive thyroid gland) and reduced growth were also seen in more than 1 patient in 10. In adults, the most common side effects with IntronA used with or without ribavirin (seen in more than 1 patient in 10) are pharyngitis (sore throat), viral infection, leucopenia (low white-blood-cell counts), loss of appetite, depression, insomnia (difficulty sleeping), anxiety, emotional lability (mood swings), agitation, nervousness, dizziness, headache, impaired concentration, dry mouth, blurred vision, dyspnoea (difficulty breathing), coughing, nausea (feeling sick) or vomiting, abdominal pain (stomach ache), diarrhoea, stomatitis (inflammation of the lining of the mouth), dyspepsia (heartburn), alopecia (hair loss), pruritus (itching), dry skin, rash, increased sweating, myalgia (muscle pain), arthralgia (joint pain), musculoskeletal pain (pain in the muscles and bones), reactions at the site of the injection including inflammation, fatigue (tiredness), rigors (shaking chills), pyrexia (fever), flu-like symptoms, asthenia (weakness), irritability, chest pain, malaise (feeling unwell) and weight loss. The medicine can only be obtained with a prescription. IntronA is used after surgery in patients whose melanoma could come back.
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long-term hepatitis B (a disease of the liver due to infection with the hepatitis-B virus) in adults (aged 18 years and older).IntronA is used for the treatment of the following diseases:
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